Article
Phenotypic and genetic heterogeneity in a genome-wide linkage study of asthma families.
BMC pulmonary medicine - 5 Jan 2005
Altmüller Janine, Seidel Corinna, Lee Young-Ae, Loesgen Sabine, Bulle Dieter, Friedrichs Frank, Jellouschek Heidemarie, Kelber Julika, Keller Angela, Schuster Antje, Silbermann Michael, Wahlen Wolfgang, Wolff Peter, Schlenvoigt Gerhard, Rüschendorf Franz, Nürnberg Peter, Wjst Matthias
Abstract excerpt
BACKGROUND: Asthma is a complex genetic disease with more than 20 genome-wide scans conducted so far. Regions on almost every chromosome have been linked to asthma and several genes have been associated. However, most of these associations are weak and are still awaiting replication. METHODS: In this study, we conducted a second-stage genome-wide scan with 408 microsatellite markers on 201 asthma-affected sib...
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