Article
Linkage analysis of bronchial hyperreactivity and atopy with chromosome 11q13.
Electrophoresis - 1 Aug 1997
Wong Z Y, Tsonis D, van Herwerden L, Raven J, Forbes A, Abramson M J, Walters E H, Harrap S B
Abstract excerpt
There are two key clinical features of asthma: allergy and bronchial hyperreactivity (BHR). Some pedigree studies of atopy have indicated linkage with the high affinity IgE receptor (Fc epsilon RI-beta) gene on chromosome 11q13, but others failed to confirm this linkage. We examined the genetic linkage of three polymorphic microsatellite markers to atopy and BHR in 120 affected sibling pairs recruited from the...
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