Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy.

doi:10.1056/NEJM199510053331402

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Article

Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy.

The New England journal of medicine - 5 Oct 1995

Postma D S, Bleecker E R, Amelung P J, Holroyd K J, Xu J, Panhuysen C I, Meyers D A, Levitt R C

Abstract excerpt

BACKGROUND: Bronchial hyperresponsiveness, a risk factor for asthma, consists of a heightened bronchoconstrictor response to a variety of stimuli. The condition has a heritable component and is closely related to serum IgE levels and airway inflammation. The basis for these relations is unknown, as is the mechanism of genetic susceptibility to bronchial hyperresponsiveness. We attempted to define the...

Topics

Adolescent
Adult
Aged
Asthma
Bronchial Hyperreactivity
Child
Chromosomes, Human, Pair 5
Female
Genes, Immunoglobulin
Genetic Linkage
Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Humans

Hypersensitivity, Immediate

Immunoglobulin E

Male

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 7666875
DOI: 10.1056/NEJM199510053331402

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7666875-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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