Linkage analysis of markers on chromosome 11q13 with asthma and atopy in a United Kingdom population.

doi:10.1164/ajrccm.162.4.9909078

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Article

Linkage analysis of markers on chromosome 11q13 with asthma and atopy in a United Kingdom population.

American journal of respiratory and critical care medicine - 1 Oct 2000

Simon Thomas N, Wilkinson J, Lonjou C, Morton N E, Holgate S T

Abstract excerpt

Previous studies have suggested that atopy is linked to the beta chain of the high affinity IgE receptor (Fcepsilon R1-beta) on chromosome 11q13. Fcepsilon R1-beta polymorphisms, I181L, V183L, and E237G, are reported to be associated with asthma and atopy. The aim of this study was to investigate linkage to Fcepsilon R1-beta in a UK population and to assess the frequency of the polymorphisms and their association...

Topics

Adult
Asthma
Child
Chromosome Mapping
Chromosomes, Human, Pair 11
England
Female
Genetic Markers
Genetic Predisposition to Disease
Humans
Male
Phenotype
Receptors, IgE
Respiratory Hypersensitivity

Source

Open in PubMed

Identifiers

PMID: 11029329
DOI: 10.1164/ajrccm.162.4.9909078

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