Is the induction of pyrimidine cyclobutane dimers relevant for the high cytotoxic effect of 7-methylpyrido[3,4-c]psoralen plus UV-A?

doi:10.1016/0921-8777(90)90075-g

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Article

Is the induction of pyrimidine cyclobutane dimers relevant for the high cytotoxic effect of 7-methylpyrido[3,4-c]psoralen plus UV-A?

Mutation research - 1 May 1990

Nocentini S

Abstract excerpt

Recently, it was shown that the photoactivation of 7-methylpyrido[3,4-c]psoralen (MPP), a highly phototoxic monofunctional compound, as well as leading to the direct cycloaddition of the molecule to pyrimidine bases, also induces the dimerization of adjacent pyrimidines in DNA in vitro (Moysan et...

Topics

Animals
Cell Survival
Cells, Cultured
Chlorocebus aethiops
DNA
Dose-Response Relationship, Radiation
Furocoumarins
Methoxsalen
Mutagens
Mutation
Pyrimidine Dimers
Ultraviolet Rays

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