Article
Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells.
Nucleic acids research - 1 Jan 2007
Couvé-Privat Sophie, Macé Gaëtane, Rosselli Filippo, Saparbaev Murat K
Abstract excerpt
Interstrand cross-link (ICL) is a covalent modification of both strands of DNA, which prevents DNA strand separation during transcription and replication. Upon photoactivation 8-methoxypsoralen (8-MOP+UVA) alkylates both strands of DNA duplex at the 5,6-double bond of thymidines, generating monoadducts (MAs) and ICLs. It was thought that bulky DNA lesions such as MAs are eliminated only in the nucleotide excision...
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