Article
Implications of results of molecular epidemiology on DNA adducts, their repair and mutations for mechanisms of human cancer.
IARC scientific publications - 1 Jan 2004
Hemminki Kari, Thilly William G
Abstract excerpt
This review covers human data on DNA adducts, their repair and induced mutations. The new data on human studies in vivo challenge some widely held notions relating to cancer and ageing. These data collected from humans of different ages show no age-dependent change in levels of diverse DNA adducts in peripheral lymphocytes, no deterioration of global DNA excision repair in skin in situ and no change in mutation...
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