Structural studies on human rhinovirus 14 drug-resistant compensation mutants.

doi:10.1006/jmbi.1995.0536

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Article

Structural studies on human rhinovirus 14 drug-resistant compensation mutants.

Journal of molecular biology - 13 Oct 1995

Hadfield A T, Oliveira M A, Kim K H, Minor I, Kremer M J, Heinz B A, Shepard D, Pevear D C, Rueckert R R, Rossmann M G

Abstract excerpt

Structures have been determined of three human rhinovirus 14 (HRV14) compensation mutants that have resistance to the antiviral capsid binding compounds WIN 52035 and WIN 52084. In addition, the structure of HRV14 is reported, with a site-directed mutation at residue 1219 in VP1. A spontaneous mu...

Topics

Antiviral Agents
Binding, Competitive
Capsid
Crystallography, X-Ray
Drug Resistance, Microbial
Humans
Intercellular Adhesion Molecule-1
Isoxazoles
Mutation
Protein Conformation
Receptors, Virus
Rhinovirus
Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 7473717
DOI: 10.1006/jmbi.1995.0536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7473717-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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