Article
Acid-induced structural changes in human rhinovirus 14: possible role in uncoating.
Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1992
Giranda V L, Heinz B A, Oliveira M A, Minor I, Kim K H, Kolatkar P R, Rossmann M G, Rueckert R R
Abstract excerpt
X-ray diffraction data were collected from human rhinovirus 14 crystals a few minutes after exposure to acid vapor and prior to excessive crystalline disorder. Conformational changes occurred (i) in the GH loop of viral protein (VP) 1, (ii) at the ion binding site on the outer surface of the pent...
Topics
- Amino Acid Sequence
- Capsid
- Capsid Proteins
- HeLa Cells
- Humans
- Hydrogen-Ion Concentration
- Models, Molecular
- Mutation
- Protein Conformation
- Rhinovirus
- Viral Plaque Assay
- X-Ray Diffraction