Article
Human rhinovirus mutants resistant to low pH.
Virology - 1 Aug 1991
Skern T, Torgersen H, Auer H, Kuechler E, Blaas D
Abstract excerpt
Mutants of human rhinovirus serotype 14 (HRV14) with increased resistance to treatment at low pH were obtained by repeated cycles of exposure to pH 4.5 and propagation in HeLa cells. Whereas wild-type virus lost more than 5 logs of infectivity upon incubation at pH 4.3, the three isolates examined were essentially unaffected. Conformational change of the viral capsid upon exposure to low pH was assessed as an...
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