Pathogenicity for humans of human rhinovirus type 2 mutants resistant to or dependent on chalcone Ro 09-0410.

doi:10.1128/AAC.34.6.963

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Article

Pathogenicity for humans of human rhinovirus type 2 mutants resistant to or dependent on chalcone Ro 09-0410.

Antimicrobial agents and chemotherapy - 1 Jun 1990

Yasin S R, al-Nakib W, Tyrrell D A

Abstract excerpt

Mutants of human rhinovirus type 2 (HRV-2) resistant to and dependent on the antirhinoviral compound chalcone Ro 09-0410 were selected in cell culture under clean laboratory conditions. A total of 42 volunteers were challenged with either the drug-resistant mutant [SR2-410(r)] (15 volunteers), th...

Topics

Adolescent
Adult
Antiviral Agents
Chalcone
Chalcones
Drug Resistance, Microbial
Female
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Mutation
Neutralization Tests
Propiophenones
Random Allocation
Rhinovirus

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