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Article

Inhibition of DNA synthesis is not sufficient to cause mutagenesis in Chinese hamster cells.

Biochimie - 1 Jan 2000

Rossman T G, Stone-Wolff D S

Abstract excerpt

Experiments were designed to test whether the inhibition of DNA synthesis in Chinese hamster V79 cells would result in increased mutagenesis by a mechanism similar to "SOS repair" in E. coli. Treatment of cells for 16 hours with excess of the deoxynucleosides TdR, UdR, AdR and GdR was mutagenic, whereas treatment with hydroxyurea demonstrated no mutagenic effect. The mutagenicity of TdR could be reversed by the...

Topics

Animals
Cell Line
Cricetinae
Cricetulus
DNA Replication
Deoxyribonucleosides
Dose-Response Relationship, Drug
Hydroxyurea
Kinetics
Lung
Mutagens
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thymidine

Ultraviolet Rays

Source

Identifiers

PMID: 6814532
DOI: 10.1016/s0300-9084(82)80134-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6814532-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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