Article
Inhibition of Escherichia coli K12 by short-chain organic acids: lack of evidence for induction of the SOS response.
The Journal of applied bacteriology - 1 Feb 1991
Cherrington C A, Hinton M, Pearson G R, Chopra I
Abstract excerpt
Sublethal concentrations of formic acid (10 mmol/l) and propionic acid (5 mmol/l) at pH 5.0 preferentially inhibit DNA synthesis and stop cell multiplication in the absence of a corresponding cessation in the increase of culture turbidity. The possibility that the acids induce the SOS response by starving cells of thymine or by causing physical damage to the DNA molecule has now been investigated. Accumulation of...
Topics
- DNA Repair
- DNA, Bacterial
- Escherichia coli
- Formates
- Microscopy, Electron
- Mutation
- Propionates
- SOS Response, Genetics
- Thymine