3-Aminobenzamide enhances dexamethasone-mediated mouse thymocyte depletion in vivo: implication for a role of poly ADP-ribosylation in the negative selection of immature thymocytes.

Abstract excerpt

3-Aminobenzamide (3-ABAm), an inhibitor of poly ADP-ribosylation, was here found to remarkably enhance the dexamethasone (Dex)-mediated depletion of total mouse thymocytes within 24 h post-injection, when given i.p. in combination with Dex. After treatment the total thymocytes were fractionated by Percoll gradient centrifugation into two mitogen-unresponsive (high- and medium-density) and one mitogen-reactive...

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