Article
3-Aminobenzamide enhances dexamethasone-mediated mouse thymocyte depletion in vivo: implication for a role of poly ADP-ribosylation in the negative selection of immature thymocytes.
Biochimica et biophysica acta - 15 Dec 1994
Hoshino J, Koeppel C, Westhäuser E
Abstract excerpt
3-Aminobenzamide (3-ABAm), an inhibitor of poly ADP-ribosylation, was here found to remarkably enhance the dexamethasone (Dex)-mediated depletion of total mouse thymocytes within 24 h post-injection, when given i.p. in combination with Dex. After treatment the total thymocytes were fractionated b...
Topics
- Animals
- Benzamides
- CD4-CD8 Ratio
- Cell Survival
- Dexamethasone
- Drug Synergism
- Flow Cytometry
- Lymphocyte Depletion
- Male
- Mice
- Phenotype
- T-Lymphocyte Subsets
- Thymus Gland