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Article

Differential cytotoxic effects of mizoribine and its aglycone on human and murine cells and on normal and enzyme-deficient human cells.

Biochemical pharmacology - 28 Sept 1995

Terai C, Hakoda M, Yamanaka H, Kamatani N, Kashiwazaki S

Abstract excerpt

The growth inhibitory mechanisms of mizoribine, an immunosuppressive imidazole nucleoside used clinically to inhibit rejection reactions after renal transplantation and in the treatment of systemic lupus erythematosus and rheumatoid arthritis, were studied in human and murine cells. We found that (a) human cells were 20- to 60-fold more resistant than murine cells to both mizoribine and its aglycone, (b) adenine...

Topics

Adenine Phosphoribosyltransferase
Adenosine Triphosphate
Animals
Anti-Inflammatory Agents, Non-Steroidal
Cell Division
Cell Line
Cell Line, Transformed
Cells, Cultured
Guanosine Triphosphate
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hypoxanthine Phosphoribosyltransferase

Immunosuppressive Agents

Mice

Mutation

Ribonucleosides

Source

Identifiers

PMID: 7575667
DOI: 10.1016/0006-2952(95)00232-o

Genes

APRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7575667-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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