Article
Inhibitor of poly(ADP-ribose)transferase potentiates the recombinogenic but not the mutagenic action of alkylating agents in somatic cells in vivo in Drosophila melanogaster.
Mutagenesis - 1 Sept 1990
Magnusson J, Ramel C
Abstract excerpt
The effect on somatic mutations and recombination by 3-aminobenzamide (3-ABA), an inhibitor of poly(ADP-ribose) transferase, was studied in the somatic wing spot test in Drosophila melanogaster, 3-ABA did not exert any effect by itself, but caused a strong increase of wing spots in combination wi...
Topics
- Alkylating Agents
- Animals
- Benzamides
- Dose-Response Relationship, Drug
- Drosophila melanogaster
- Ethylnitrosourea
- Heterozygote
- Methyl Methanesulfonate
- Mutation
- Phenotype
- Poly(ADP-ribose) Polymerase Inhibitors
- Recombination, Genetic