Article
Idiotypic inheritance: allelic relationships between immunoglobin genes.
Annales d'immunologie - 1 Jan 2000
Bothwell A L
Abstract excerpt
An analysis of genes related to the expressed VH region of anti-NP antibodies in C57BL/6 mice showed that 24 distinct genes could be grouped into 3 subfamilies. Some of these genes showed striking homology with a family found in BALB/c mice. The extension of diversity through gene conversion seems to be very important in the VH family.
Topics
- Alleles
- Animals
- Cloning, Molecular
- Genes
- Immunoglobulin Idiotypes
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
