[Molecular genetic analysis of a cold-adapted donor attenuation strain for a pediatric liver influenza vaccine, of recombinants based on it and of isolates from vaccinated children].

Abstract excerpt

The recombination test demonstrated that in the genome of a highly attenuated cold-adapted variant of influenza A/Leningrad/134/47/57 virus five genes coding for nonglycosylated proteins (1, 2, 5, 7, 8) carried ts mutations. Hybridization of this variant with epidemically important strains of influenza H1N1 and H3N2 viruses produced recombinants which inherited hemagglutinin and neuraminidase from the epidemic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Child
• Share to Genes, Viral