Article
[Molecular genetic analysis of a cold-adapted donor attenuation strain for a pediatric liver influenza vaccine, of recombinants based on it and of isolates from vaccinated children].
Voprosy virusologii - 1 Jan 2000
Gendon Iu Z, Klimov A I, Lisovskaia K V, Aleksandrova G I, Medvedeva T I
Abstract excerpt
The recombination test demonstrated that in the genome of a highly attenuated cold-adapted variant of influenza A/Leningrad/134/47/57 virus five genes coding for nonglycosylated proteins (1, 2, 5, 7, 8) carried ts mutations. Hybridization of this variant with epidemically important strains of inf...
Topics
- Adaptation, Physiological
- Child
- Cold Temperature
- Genes, Viral
- Humans
- Influenza A virus
- Influenza Vaccines
- Mutation
- Nucleic Acid Hybridization
- Phenotype
- RNA, Viral
- Recombination, Genetic
- Temperature
- Vaccines, Attenuated