Article
[Genetic basis for construction of the life influenza type A vaccine using temperature-sensitive mutants].
Molekuliarnaia genetika, mikrobiologiia i virusologiia - 1 Mar 1990
Aleksandrova G I, Gushchina M I, Klimov A I, Iotov V V
Abstract excerpt
Published data and authors' original material on the use of temperaturesensitive influenza virus mutants (ts) as donors in attenuation process aimed at obtaining the recombinant live influenza vaccines (LIV) are reviewed. The so called cold adapted ts donors are shown to be superior for this aim....
Topics
- Humans
- Influenza A virus
- Influenza Vaccines
- Mutation
- Temperature