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Article

Anti-idiotypic cytotoxic T cells in rats with graft-versus-host disease.

Nature - 1 Jan 2000

Kimura H, Wilson D B

Abstract excerpt

Transfer of parental strain T lymphocytes into F1 hybrid rats differing with respect to gene products of the major histocompatibility complex (MHC) causes a graft-versus-host (GvH) reaction. This reaction results from recognition of host allogeneic MHC gene products by specific clones of donor T cells. When given systemically in sufficient numbers, these donor T cells cause a progressive, generally fatal wasting...

Topics

Animals
Antigens, Surface
Cytotoxicity, Immunologic
Graft vs Host Disease
Immunoglobulin Idiotypes
Killer Cells, Natural
Major Histocompatibility Complex
Phenotype
Rats
T-Lymphocytes

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Identifiers

PMID: 6608695
DOI: 10.1038/308463a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6608695-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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