Article
Cytotoxic T-cell precursors with low-level CD8 in the diabetes-prone Biobreeding rat: implications for generation of an autoimmune T-cell repertoire.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990
Bellgrau D, Lagarde A C
Abstract excerpt
Lymphocytes from diabetes-prone Biobreeding rats consistently fail to generate T-cell-mediated cytotoxicity under conditions where cytotoxic T lymphocyte activity is readily demonstrated in normal rats. The failure is associated with generalized T-cell lymphopenia and marked reduction in the frequency of CD8+ cells. The few remaining CD8+ cells are widely held to be natural killer cells rather than class I major...
Topics
- Animals
- Antigens, Differentiation, T-Lymphocyte
- Autoimmunity
- CD8 Antigens
- Cytotoxicity, Immunologic
- Diabetes Mellitus, Experimental
- Disease Susceptibility
- Histocompatibility Antigens Class I
- Phenotype
- Rats