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Article

A major role for the Fas pathway in acute graft-versus-host disease

1 Dec 1996

Abstract excerpt

Recent studies have suggested a role for the Fas pathway in the wasting syndrome associated with lpr-->wild-type bone marrow transplants. To directly examine whether Fas ligand has a major role in the development of acute graft-vs-host disease (GVHD), Fas ligand-deficient (gld) mice were used as donors and C3H/HeJ x C57BL/6F1 as recipients in the parent-into-F1 model of acute GVHD. Transplantation of C3H/gld...

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Identifiers

PMID: 8955186
DOI: 10.4049/jimmunol.157.12.5387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A major role for the Fas pathway in acute graft-versus-host diseasePMID 8955186Read ↗

Fas-deficient lpr mice are more susceptible to graft-versus-host disease.Semantic proximity Read ↗

Fas receptor signaling is requisite for B cell differentiation.Semantic proximity Read ↗

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Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.Semantic proximity Read ↗

Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene.Semantic proximity Read ↗

Differential Requirement for IFN-γ in CTL Maturation in Acute Murine Graft-versus-Host DiseaseSemantic proximity Read ↗

A Fas-based suicide switch in human T cells for the treatment of graft-versus-host diseaseSemantic proximity Read ↗

Fas and Fas ligand: lpr and gld mutations.Semantic proximity Read ↗

A Fas-based suicide switch in human T cells for the treatment of graft-versus-host diseaseSemantic proximity Read ↗

Functional distinctions between MRL-lpr and MRL-gld lymphocytes. Normal cells reverse the gld but not lpr immunoregulatory defect.Semantic proximity Read ↗

Blockade of Programmed Death-1 Engagement Accelerates Graft-Versus-Host Disease Lethality by an IFN-γ-Dependent MechanismSemantic proximity Read ↗

Protection from autoimmune diabetes and T-cell lymphoproliferation induced by FasL mutation are differentially regulated and can be uncoupled pharmacologically.Semantic proximity Read ↗

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