Article
Induction of a glucocorticoid-sensitive F1-anti-parental mechanism that affects engraftment during graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1995
You-Ten K E, Seemayer T A, Wisse B, Bertley F M, Lapp W S
Abstract excerpt
Studies have shown that graft-vs-host disease (GVHD) in animal models induces persistent elevated levels of circulating adrenal glucocorticoids. In this report, we investigated the effects of endogenous glucocorticoids on the outcome of GVHD by adrenalectomizing (ADX) unirradiated (C57BL/6 x A)F1...
Topics
- Adrenalectomy
- Animals
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Separation
- Cell Transplantation
- Cortisone
- Female
- Flow Cytometry
- Glucocorticoids
- Graft Rejection
- Graft vs Host Disease
- Hybrid Vigor
- Immunosuppression Therapy
- Liver
- Lymph Nodes
- Male
- Mice