Article
Alloreactive natural killer cells in the rat: complex genetics of major histocompatibility complex control.
European journal of immunology - 1 May 1995
Naper C, Vaage J T, Lambracht D, Løvik G, Butcher G W, Wonigeit K, Rolstad B
Abstract excerpt
A major role for the nonclassical major histocompatibility complex (MHC) class I region, i.e. RT1.C, in controlling rat natural killer (NK) cell alloreactivity has recently been established, and several findings suggested the existence of NK-triggering alloantigens coded for by this region. Here, we have extended our studies on the MHC control of NK cell cytotoxicity against concanavalin A-activated T cell blasts...
Topics
- Alleles
- Animals
- Concanavalin A
- Crosses, Genetic
- Cytotoxicity, Immunologic
- Female
- Genes, Recessive
- Histocompatibility Antigens
- Interleukin-2
- Killer Cells, Natural
- Lymphocyte Activation