Article
Chlornaphazine and chlorambucil induce dominant lethal mutations in male mice.
Mutation research - 1 Mar 2003
Barnett Lois B, Lewis Susan E
Abstract excerpt
Two antineoplastic agents, chlornaphazine (CN) and chlorambucil (CHL), were tested for the induction of dominant lethal mutations in male mice. Both compounds are nitrogen mustard derivatives and have been shown to be genotoxic in a variety of organisms. CN was administered intraperitoneally to DBA/2J male mice at a dosage of 0, 500, 1000, or 1500 mg/kg body weight (bw). Immediately following treatment, each male...
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