Article
Antimitotic drugs in the male rat. Behavioral abnormalities in the second generation.
Journal of andrology - 1 Jan 2000
Auroux M R, Dulioust E J, Nawar N N, Yacoub S G, Mayaux M J, Schwartz D, David G
Abstract excerpt
The second generation descended from rats treated either with cyclophosphamide alone or with both cyclophosphamide and vinblastine were investigated. As in the first generation, the offspring were evaluated for mean litter size, sex ratio, frequency of gross external malformations and, within the first 4 months of life, growth and mortality. When they reached adulthood, between 12 and 16 weeks of age, the...
Topics
- Animals
- Behavior, Animal
- Cyclophosphamide
- Female
- Learning
- Male
- Mutation
- Rats
- Rats, Inbred Strains
- Vinblastine