Male-mediated dominant lethal mutations in mice following prooxidant treatment.

doi:10.1016/s1383-5718(99)00085-6

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Article

Male-mediated dominant lethal mutations in mice following prooxidant treatment.

Mutation research - 21 Jul 1999

Kumar T R, Muralidhara

Abstract excerpt

This study's primary aim is to examine if prooxidant treatment has the propensity to induce dominant lethal (DL) type mutations in a randomly bred closed colony of CFT-Swiss mice. Initially, graded doses of both organic hydroperoxides viz., t-butyl hydroperoxide (tbHP), and cumene hydroperoxide (cHP) were administered (i.p.) to adult males and the mortality data was analysed to determine the LD(50) values. cHP...

Topics

Animals
Benzene Derivatives
Female
Fetal Death
Genes, Dominant
Genes, Lethal
Lethal Dose 50
Male
Mice
Mutagens
Mutation
Oxidants
Pregnancy
Spermatogenesis
tert-Butylhydroperoxide

Source

Open in PubMed

Identifiers

PMID: 10477348
DOI: 10.1016/s1383-5718(99)00085-6

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