Article
Heritable translocation study in male mice with trimethyl phosphate.
Mutation research - 1 Jan 2000
Tezuka H, Sasaki Y F, Inoue M, Uchida A, Moriya M, Shirasu Y
Abstract excerpt
Dominant lethal and heritable translocation studies were performed in male mice receiving a single intraperitoneal injection of trimethyl phosphate (TMP). The germ cell stage investigated was the spermatid. Methyl methanesulfonate (MMS) was used as a positive control in the latter study. A dominant lethal assay gave marked dose-dependent increases in early fetal deaths. Heritable translocations were detected at...
Topics
- Animals
- Female
- Fetal Death
- Genes, Dominant
- Genes, Lethal
- Karyotyping
- Male
- Mice
- Mice, Inbred C3H
- Mutagenicity Tests
- Mutation
- Organophosphates