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Article

V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses

10 Oct 1997

Abstract excerpt

The clonal selection theory states that B lymphocytes producing high-affinity immunoglobulins are selected from a pool of cells undergoing antibody gene mutation. Somatic hypermutation is a well-documented mechanism for achieving diversification of immune responses in mature B cells. Antibody genes were also found to be modified in such cells in germinal centers by recombination of the variable (V), diversity...

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PMID: 9323210
DOI: 10.1126/science.278.5336.298

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