Article
Molecular characterization of five human anti-human immunodeficiency virus type 1 antibody heavy chains reveals extensive somatic mutation typical of an antigen-driven immune response.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1991
Andris J S, Johnson S, Zolla-Pazner S, Capra J D
Abstract excerpt
We report the heavy chain variable region sequences from the cDNAs of five previously described monoclonal cell lines producing human antibodies specific for the human immunodeficiency virus type 1 and detail the molecular characteristics, germ-line origins, and extent of somatic mutation among these antibodies. Three of the five heavy chain variable regions derive from the VHIV gene family, but each has arisen...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Antibody Formation
- Base Sequence
- Cell Line
- Cloning, Molecular
- Genes, Immunoglobulin
- HIV Antibodies
- HIV-1
- Humans