Article
Human T-cell gamma genes contain N segments and have marked junctional variability.
Nature - 1 Jan 2000
Quertermous T, Strauss W, Murre C, Dialynas D P, Strominger J L, Seidman J G
Abstract excerpt
The gamma-chain genes are encoded by immunoglobulin-like gene segments in germline DNA which rearrange during the somatic development of T cells to form an active gene. The protein produced by these genes has not been identified and the diversity of the proteins that the genes can express has not been determined. We expect that the diversity of expressed gamma-chains is produced by the same three mechanisms that...
Topics
- Base Sequence
- DNA
- Genes
- Humans
- Mutation
- Nucleic Acid Hybridization
- Receptors, Antigen, T-Cell