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Article

Mutagens in rat urine after dermal application of 1,3-diaminobenzene.

Mutation research - 1 Jan 2000

Clemmensen S, Lam H R

Abstract excerpt

The mutagenicity of urine from rats treated topically on the skin with 1,3-diaminobenzene was studied by the Salmonella/mammalian-microsome assay. Urine samples were either passed directly through micropore filters or extracts were prepared using XAD-2 resin before testing in the frameshift strain TA98. Significant mutagenic activity was found only after metabolic activation with rat-liver microsomes. The...

Topics

Animals
Biotransformation
Male
Microsomes, Liver
Mutagenicity Tests
Mutagens
Mutation
Phenylenediamines
Rats
Rats, Inbred Strains
Salmonella typhimurium
Skin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 6392872
DOI: 10.1016/0165-1218(84)90036-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6392872-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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