Article
Formation of 2-amino-3,7,8-trimethylimidazo [4,5-f]quinoxaline, a new mutagen, by heating a mixture of creatinine, glucose and glycine.
Mutation research - 1 Jan 2000
Negishi C, Wakabayashi K, Tsuda M, Sato S, Sugimura T, Saitô H, Maeda M, Jägerstad M
Abstract excerpt
When a mixture of creatinine, glycine and glucose was heated for 2 h at 128 degrees C in diethylene glycol containing 14% water, two mutagens were formed. One of them, responsible for 90% of the mutagenicity, has already been identified as 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). Th...
Topics
- Chemical Phenomena
- Chemistry
- Chromatography, High Pressure Liquid
- Creatinine
- Glucose
- Glycine
- Hot Temperature
- Magnetic Resonance Spectroscopy
- Mass Spectrometry
- Mutagenicity Tests
- Mutagens
- Mutation
- Quinolines
- Quinoxalines
- Salmonella typhimurium
- Spectrophotometry, Ultraviolet