Article
3-Methoxy-4-aminoazobenzene, a unique carcinogenic aromatic amine as a substrate for cytochrome-P-450-mediated mutagenesis.
Mutation research - 1 Jan 2000
Degawa M, Kojima M, Hashimoto Y
Abstract excerpt
Rat liver microsomal enzyme(s) that catalyze mutagenic activation of a carcinogenic aminoazo dye, 3-methoxy-4-aminoazobenzene (3-MeO-AAB), was studied by virtue of the Salmonella typhimurium TA98 assay using o-aminoazotoluene (OAT) as the control. Male Wistar rats were pretreated with phenobarbit...
Topics
- Animals
- Azo Compounds
- Biotransformation
- Carcinogens
- Cytochrome P-450 Enzyme System
- Kinetics
- Male
- Methylcholanthrene
- Microsomes, Liver
- Mutagenicity Tests
- Mutation
- Phenobarbital
- Polychlorinated Biphenyls
- Rats
- Rats, Inbred Strains
- Salmonella typhimurium
- p-Aminoazobenzene