Metabolic activation and deactivation of mutagens and carcinogens.

Article

Metabolic activation and deactivation of mutagens and carcinogens.

The Italian journal of biochemistry - 1 Jan 2000

De Flora S

Abstract excerpt

The activity of some mutagens has been investigated in the Salmonella test either in the absence or in the presence of fortified rat liver microsomal fractions, together with an NADPH-generating system. With respect to their metabolic reactivity, the compounds tested could be distinguished accord...

Topics

Animals
Biotransformation
Carcinogens
Drug Evaluation, Preclinical
In Vitro Techniques
Inactivation, Metabolic
Microsomes, Liver
Mutagens
Mutation
Rats
Salmonella typhimurium

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