Article
Interaction with the aromatic hydrocarbon receptor, CYP1A induction, and mutagenicity of a series of diaminotoluenes: implications for their carcinogenicity.
Toxicology and applied pharmacology - 1 Jul 1996
Cheung Y L, Snelling J, Mohammed N N, Gray T J, Ioannides C
Abstract excerpt
The present study was undertaken to provide a rationale for the marked difference in carcinogenic potential among isomeric diaminotoluenes, in relation to their ability to induce their own bioactivation through CYP1A induction, their genotoxic potential, and their ability to bind to the cytosolic...
Topics
- Animals
- Aroclors
- Binding Sites
- Carcinogens
- Chlorodiphenyl (54% Chlorine)
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 Enzyme System
- Electrophoresis, Polyacrylamide Gel
- Enzyme Induction
- Male
- Mutagens