Article
Identification of an antigenic site in the neutralization of type 3 poliovirus.
Reviews of infectious diseases - 1 Jan 2000
Minor P D, Evans D M, Schild G C, Ferguson M, Almond J W
Abstract excerpt
Antigenic mutants of type 3 poliovirus were obtained by picking plaques formed in the presence of neutralizing monoclonal antibodies. All the mutants were clustered into a single operationally defined antigenic site based on their reactions with a panel of antibodies. Most of the mutations were shown to be located in the virion protein VP1 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and...
Topics
- Base Sequence
- Binding Sites, Antibody
- Mutation
- Neutralization Tests
- Oligonucleotides
- Poliovirus