Article
Identification of residues in VP2 that contribute to poliovirus neutralization antigenic site 3B.
Virology - 1 Sept 1991
Reynolds C, Page G, Zhou H, Chow M
Abstract excerpt
Amino acid substitutions were placed at residues 74, 243, and 246 in capsid protein VP2 of poliovirus serotype 1, using site-specific mutagenesis methods. The proximity of these residues to those previously identified in neutralization site 3B suggests that these residues may also contribute to neutralization site 3B and potentially be under antibody selective pressure to mutate. However, sequence analyses of...
Topics
- Amino Acid Sequence
- Base Sequence
- Capsid
- Capsid Proteins
- Epitopes
- Genes, Viral
- HeLa Cells
- Humans
- Models, Molecular
- Molecular Sequence Data
- Neutralization Tests
- Phenotype