Article
A Sabin vaccine-derived field isolate of poliovirus type 1 displaying aberrant phenotypic and genetic features, including a deletion in antigenic site 1.
The Journal of general virology - 1 Apr 1999
Mulders M N, Reimerink J H, Stenvik M, Alaeddinoglu I, van der Avoort H G, Hovi T, Koopmans M P
Abstract excerpt
Poliovirus strains derived from the oral poliovirus vaccine (Sabin) can be differentiated from wild-type poliovirus by tests based on either immunological or genetic properties of the strains. The characterization of a recently identified poliovirus type 1 isolate with exceptional properties is described. Initial phenotypic analysis of the virus by use of polyclonal absorbed antisera suggested a wild-type...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Line
- Child
- Gene Deletion
- Humans
- Male
- Molecular Sequence Data
- Phenotype
- Poliovirus
- Poliovirus Vaccine, Oral