Article
Antigenic structure of chimeras of type 1 and type 3 poliovirus involving antigenic site 1.
The Journal of general virology - 1 Nov 1990
Minor P D, Ferguson M, Katrak K, Wood D, John A, Howlett J, Dunn G, Burke K, Almond J W
Abstract excerpt
Chimeric polioviruses have been prepared in which part of the antigenic site 1-encoding sequence of the Sabin strain of type 1 poliovirus has been replaced by sequences based on those found in the homologous region of the Sabin type 3 strain. The chimeras were analysed for their reaction with polyclonal and monoclonal antibodies raised against type 1 and type 3 viruses, and with polyclonal antipeptide sera, as...
Topics
- Animals
- Antibodies, Monoclonal
- Antibodies, Viral
- Antigens, Viral
- Binding, Competitive
- Chimera
- Epitopes
- Humans
- Mutation
- Poliovirus
- Poliovirus Vaccine, Oral