Localization of rotavirus VP4 neutralization epitopes involved in antibody-induced conformational changes of virus structure.

doi:10.1128/JVI.68.6.3955-3964.1994

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Article

Localization of rotavirus VP4 neutralization epitopes involved in antibody-induced conformational changes of virus structure.

Journal of virology - 1 Jun 1994

Zhou Y J, Burns J W, Morita Y, Tanaka T, Estes M K

Abstract excerpt

We previously characterized three neutralization-positive epitopes (NP1 [1a and 1b], NP2, and NP3) and three neutralization-negative epitopes on the simian rotavirus SA11 VP4 with 13 monoclonal antibodies (MAbs). Conformational changes occurred as a result of the binding of NP1 MAbs to the SA11 spike VP4, and enhanced binding of all neutralization-negative MAbs was observed when NP1 MAbs bound VP4 in a...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antibodies, Viral
Antigens, Viral
Base Sequence
Binding, Competitive
Capsid
Capsid Proteins
DNA, Viral
Epitopes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Viral

Microscopy, Electron

Molecular Sequence Data

Neutralization Tests

Phenotype

Point Mutation

Protein Conformation

Source

Open in PubMed Open full text

Identifiers

PMID: 7514681
DOI: 10.1128/JVI.68.6.3955-3964.1994
PMCID: PMC236901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7514681-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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