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Article

Localization of rotavirus VP4 neutralization epitopes involved in antibody-induced conformational changes of virus structure.

Journal of virology - 1 Jun 1994

Zhou Y J, Burns J W, Morita Y, Tanaka T, Estes M K

Abstract excerpt

We previously characterized three neutralization-positive epitopes (NP1 [1a and 1b], NP2, and NP3) and three neutralization-negative epitopes on the simian rotavirus SA11 VP4 with 13 monoclonal antibodies (MAbs). Conformational changes occurred as a result of the binding of NP1 MAbs to the SA11 spike VP4, and enhanced binding of all neutralization-negative MAbs was observed when NP1 MAbs bound VP4 in a...

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Identifiers

PMID: 7514681
DOI: 10.1128/JVI.68.6.3955-3964.1994
PMCID: PMC236901

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Source receipt: pubmed, retrieved 7 Sept 2026.

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