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Article

Molecular basis of antigenic structures of poliovirus: implications for their evolution during morphogenesis.

Journal of virology - 1 Jul 1992

Wiegers K, Dernick R

Abstract excerpt

Neutralizing monoclonal antibodies against poliovirus type 1 were obtained after conventional immunization or combined in vivo-in vitro immunization. Antibody binding sites were determined by sequence analysis of neutralization-resistant mutants. Site 3 variants had several amino acid substitutions in previously unidentified positions for neutralization resistance. Evidence for a linkage of subsites 3a and 3b is...

Topics

Antibodies, Monoclonal
Antigens, Viral
Epitopes
Morphogenesis
Mutation
Neutralization Tests
Poliovirus
Precipitin Tests

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1376371
DOI: 10.1128/JVI.66.7.4597-4600.1992
PMCID: PMC241275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1376371-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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