Article
Location of antigenic sites defined by neutralizing monoclonal antibodies on the S1 avian infectious bronchitis virus glycopolypeptide.
The Journal of general virology - 1 Mar 1992
Kant A, Koch G, van Roozelaar D J, Kusters J G, Poelwijk F A, van der Zeijst B A
Abstract excerpt
Neutralizing monoclonal antibodies directed against five antigenic sites on the spike (S) S1 glycopolypeptide of avian infectious bronchitis virus (IBV) were used to select neutralization-resistant variants of the virus. By comparing the nucleotide sequence of such variants with the sequence of t...
Topics
- Antibodies, Monoclonal
- Chromosome Mapping
- Coronaviridae Infections
- DNA Mutational Analysis
- Epitopes
- Genetic Variation
- Glycoproteins
- Infectious bronchitis virus
- Membrane Glycoproteins
- Protein Conformation
- Spike Glycoprotein, Coronavirus