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Article

Multiple genetic abnormalities of 11p15 in Wilms' tumor.

Medical and pediatric oncology - 1 Nov 1996

Feinberg A P

Abstract excerpt

Wilms' tumor has served as a model of multiple genetic alterations in childhood cancer. This review summarizes work in our laboratory identifying several of these alterations. These include the localization to 11p15 of an embryonal tumor suppressor gene and at least one gene for Beckwith-Wiedemann syndrome, which predisposes to Wilms' tumor; as well as a novel mutational mechanism in man, loss of imprinting.

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8827078
DOI: 10.1002/(SICI)1096-911X(199611)27:5<484::AID-MPO16>3.0.CO;2-A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Multiple genetic abnormalities of 11p15 in Wilms' tumor.PMID 8827078Read ↗

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Tumor development in the Beckwith-Wiedemann syndrome is associated with a variety of constitutional molecular 11p15 alterations including imprinting defects of KCNQ1OT1.Semantic proximity Read ↗

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Stratification of Wilms tumor by genetic and epigenetic analysis.Semantic proximity Read ↗

Cancer predisposition signaling in Beckwith-Wiedemann Syndrome drives Wilms tumor development.Semantic proximity Read ↗

Genetic and epigenetic alterations on the short arm of chromosome 11 are involved in a majority of sporadic Wilms' tumours.Semantic proximity Read ↗

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