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Article

Loss of a Harvey ras allele in sporadic Wilms' tumour.

Nature - 1 Jan 2000

Reeve A E, Housiaux P J, Gardner R J, Chewings W E, Grindley R M, Millow L J

Abstract excerpt

Genomic changes within chromosome band 11p13 appear to have a role in the initiation of Wilms' tumour. The human Harvey ras oncogene, c-Ha-ras 1, has been located by Jhanwar et al. immediately adjacent to this region at band 11p14 .1, although several groups have assigned the gene more distally at band 11p15 . We have examined tumour DNA from two cases of sporadic Wilms' tumour, and report here that in both cases...

Topics

Alleles
Base Sequence
Chromosomes, Human, 6-12 and X
DNA Restriction Enzymes
DNA, Neoplasm
Humans
Karyotyping
Kidney Neoplasms
Oncogenes
Translocation, Genetic
Wilms Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 6325938
DOI: 10.1038/309174a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6325938-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Loss of a Harvey ras allele in sporadic Wilms' tumour.PMID 6325938Read ↗

Loss of heterozygosity for chromosome region 11p15 in Wilms' tumours is not related to HRAS gene transforming mutations.Semantic proximity Read ↗

Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours.Semantic proximity Read ↗

Loss of heterozygosity in Wilms' tumors, studied for six putative tumor suppressor regions, is limited to chromosome 11.Semantic proximity Read ↗

Constitutional and somatic deletions of two different regions of maternal chromosome 11 in Wilms tumor.Semantic proximity Read ↗

Loss of heterozygosity in Wilms' tumour involves two distinct regions of chromosome 11.Semantic proximity Read ↗

Loss of heterozygosity at 11p13 in Wilms' tumours does not necessarily involve mutations in the WT1 gene.Semantic proximity Read ↗

Genetic and epigenetic alterations on the short arm of chromosome 11 are involved in a majority of sporadic Wilms' tumours.Semantic proximity Read ↗

Direct pulsed field gel electrophoresis of Wilms' tumors shows that DNA deletions in 11p13 are rare.Semantic proximity Read ↗

Complete physical map of the WAGR region of 11p13 localizes a candidate Wilms' tumor geneSemantic proximity Read ↗

Identification of mutations in the WT1 gene in tumours from patients with the WAGR syndrome.Semantic proximity Read ↗

Allelotyping in Wilms tumors identifies a putative third tumor suppressor gene on chromosome 11.Semantic proximity Read ↗

Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour.Semantic proximity Read ↗

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