Article
E. coli mismatch repair enhances AT-to-GC mutagenesis caused by alkylating agents.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Mar 2017
Nakano Kota, Yamada Yoko, Takahashi Eizo, Arimoto Sakae, Okamoto Keinosuke, Negishi Kazuo, Negishi Tomoe
Abstract excerpt
Alkylating agents are known to induce the formation of O6-alkylguanine (O6-alkG) and O4-alkylthymine (O4-alkT) in DNA. These lesions have been widely investigated as major sources of mutations. We previously showed that mismatch repair (MMR) facilitates the suppression of GC-to-AT mutations caused by O6-methylguanine more efficiently than the suppression of GC-to-AT mutations caused by O6-ethylguanine. However,...
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