Article
Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations.
Nature - 1 Jan 2000
Capon D J, Seeburg P H, McGrath J P, Hayflick J S, Edman U, Levinson A D, Goeddel D V
Abstract excerpt
Kirsten (Ki)-ras cDNA clones were prepared from human lung and colon carcinoma cell lines expressing an activated c-Ki-ras2 gene. DNA sequence analysis and transfection studies indicate that different point mutations at the same codon can activate the gene; that most human c-Ki-ras2 mRNA uses seq...
Topics
- Alleles
- Cell Transformation, Neoplastic
- Colonic Neoplasms
- DNA, Neoplasm
- Gene Expression Regulation
- Humans
- Kirsten murine sarcoma virus
- Lung Neoplasms
- Mutation
- Oncogenes
- RNA Splicing
- RNA, Neoplasm
- Sarcoma Viruses, Murine
- Viral Proteins