Article
Differences in in vitro invasive capacity induced by differences in Ki-Ras protein mutations.
The Journal of pathology - 1 Dec 2001
Al-Mulla F, MacKenzie E M
Abstract excerpt
The p21 proteins encoded by N-, Ki-, and H-ras are small guanine nucleotide-binding proteins that act as switches in several signal transduction pathways. Recently, evidence has been accumulating to suggest that valine-12 mutation in the Ki-Ras protein is associated with lung and colorectal tumours that are more aggressive than those carrying aspartate-12 mutation. The purpose of this study was to determine...
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