Article
Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma.
Cancer research - 15 Apr 1993
Sasaki H, Nishii H, Takahashi H, Tada A, Furusato M, Terashima Y, Siegal G P, Parker S L, Kohler M F, Berchuck A
Abstract excerpt
Previous studies have demonstrated that some human endometrial carcinomas contain an activating point mutation in codon 12 of the Ki-ras protooncogene. To examine the hypothesis that this mutation may occur at an earlier stage of neoplastic progression in the endometrium, we analyzed 89 samples of premalignant endometrial hyperplasia and an additional 84 samples of endometrial carcinoma for point mutations of...
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