Gene insertion: current progress and long-term goals.

Abstract excerpt

The methods for artificial gene insertion in the germline of the fly Drosophila and mice are now well established. In mice, cloned genes or retroviruses can be inserted by manipulation of newly fertilized ova, and intensive research is aimed at understanding the basis for regulation of gene expression using this technique. Manipulation of early embryos in the chicken is much more difficult. Therefore, we are...

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